Three-step criteria: entry criterion, sufficient criterion (MSU crystals), then scored domains. A total score of ≥8 classifies as gout.
Based on symptomatic episode(s) ever. Score reflects joint involvement during any prior or current flare. First MTP (big toe) involvement scores highest.
Count how many of these three features have been present during any symptomatic episode, ever. Each feature adds 1 point (up to 3 total).
A "typical episode" requires ≥2 of these three features, regardless of anti-inflammatory treatment: (i) time to maximal pain <24 hours, (ii) resolution of symptoms in ≤14 days, (iii) complete resolution between episodes.
A tophus is a draining or chalk-like subcutaneous nodule under transparent skin, often with overlying vascularity. Typical locations: joints, ears, olecranon bursae, finger pads, tendons (e.g., Achilles).
Measured by uricase method. Ideally scored during the intercritical period - when the patient is not taking urate-lowering therapy and >4 weeks from the start of an episode. The highest value ever should be scored. Note: values <4 mg/dL subtract 4 points.
Polarizing microscopy of synovial fluid from a symptomatic (ever) joint or bursa, assessed by a trained examiner. If fluid was not assessed, score as 0. MSU-negative fluid subtracts 2 points.
Ultrasound: double-contour sign (hyperechoic irregular enhancement over hyaline cartilage surface, independent of insonation angle). OR DECT: color-coded urate at articular or peri-articular sites. If imaging not available, score 0.
Conventional radiography (plain X-ray) of the hands and/or feet showing at least one erosion. Erosion defined as a cortical break with sclerotic margin and overhanging edge - excluding DIP joints and gull-wing appearance.
| Domain | Options | Score |
|---|---|---|
| A. Joint pattern | MTP1 / ankle-midfoot / other | 0, +1, +2 |
| B. Episode characteristics | Count of 3 features (erythema, touch, walking) | 0 to +3 |
| C. Time-course | No / one / recurrent typical episodes | 0, +1, +2 |
| D. Tophus | Absent / present | 0, +4 |
| E. Serum urate | <4 / 4-6 / 6-8 / 8-10 / ≥10 mg/dL | -4, 0, +2, +3, +4 |
| F. Synovial fluid | Not done / MSU negative | 0, -2 |
| G. Imaging - urate | Double contour sign or DECT | 0, +4 |
| H. Imaging - erosion | Radiographic erosion (hands/feet) | 0, +4 |
| Threshold for classification | ≥8 | |